Publications

Melanie A. Sparks, Peter M. Burgers, and Roberto Galletto, Pif1, RPA, and FEN1 modulate the ability of DNA polymerase δ to overcome protein barriers during DNA synthesis. J. Biol Chem, 2020 Nov 20;295(47):15883-15891. (PDF)

Review Articles

Wanrooij PH, Burgers PM. Yet another job for Dna2: Checkpoint activation. DNA Repair (Amst). 2015 Aug;32:17-23. (PDF)

Makarova AV, Burgers PM. Eukaryotic DNA polymerase ζ. DNA Repair (Amst). 2015 May;29:47-55. (PDF)Makarova AV, Burgers PM. Eukaryotic DNA polymerase ζ. DNA Repair (Amst). 2015 May;29:47-55. (PDF)

Kunkel TA, Burgers PM. Delivering nonidentical twins. Nat Struct Mol Biol. 2014 Aug;21(8):649-51. (PDF)

Navadgi-Patil, V., and Burgers, P.M. Cell cycle specific activators of the Mec1/ATR checkpoint kinase. Biochem. Soc. Trans., 39, 600-605 (2011). (PDF)

Burgers PM. It’s all about flaps: Dna2 and checkpoint activation. Cell Cycle. 2011 Aug 1;10(15):2417-8. (PDF)

Navadgi-Patil, V.M., and Burgers, P.M. A tale of two tails: Activation of DNA damage checkpoint kinase Mec1/ATR by the 9-191 clamp and by Dpb11/TopBP1. DNA Repair 8, 996-1003 (2009). (PDF)

Burgers, P. M. 2009. Polymerase dynamics at the eukaryotic DNA replication fork. J Biol Chem 284, 4041-4045 (2009). (PDF)

Kunkel, T. A., and P. M. Burgers. 2008. Dividing the workload at a eukaryotic replication fork. Trends Cell Biol 18, 521-527 (2008). (PDF)

Majka, J. and Burgers, P.M. Clamping the Mec1/ATR Checkpoint Kinase into Action. Cell Cycle 6, 1157-1160 (2007). (PDF)

Burgers, P. M., and Seo, Y. S. Eukaryotic DNA replication Forks. In DNA Replication and Human Disease, M. L. DePamphilis, ed. (Cold Spring Harbor, Cold Spring Harbor Laboratory Press), pp. 155-174 (2006).

Bylund, G. O., Majka, J., and Burgers, P. M. (2006). Overproduction and purification of RFC-related clamp loaders and PCNA-related clamps from Saccharomyces cerevisiae. Methods Enzymol 409, 1-11 (2006). (PDF)

Garg, P., and Burgers, P.M. How the cell deals with a nick. Cell Cycle, 4 221-224 (2005). (PDF)

Garg, P., and Burgers, P.M. DNA polymerases that propagate the eukaryotic DNA replication fork, Crit. Rev. Biochem. Mol. Biophys., 40 115-128 (2005). (PDF)

Majka, J. and Burgers, P.M., The PCNA-RFC Families of DNA clamps and Clamp Loaders, Progr. Nucl. Acids Res. Mol. Biol., 78, 227-260 (2004). (PDF)

Burgers, P.M.J, Koonin, E.V., Bruford, E., Blanco, L., Burtis, K.C., Christman, M.F., Copeland, W.C., Friedberg, E.C., Hanaoka, F., Hinkle, D.C., Lawrence, C.W., Nakanishi, M., Ohmori, H., Prakash, L., Prakash, S., Reynaud, C.A., Sugino, A., Todo, T., Wang, Z., Weill, J.C., Woodgate, R., Eukaryotic DNA polymerases: proposal for a revised nomenclature, J. Biol. Chem. 276, 43487-43490 (2001). (PDF)

Publications

Koc KN, Stodola JL, Burgers PM, Galletto R. Regulation of yeast DNA polymerase δ-mediated strand displacement synthesis by 5′-flaps. Nucleic Acids Res. 2015 Apr 30;43(8):4179-90. (PDF)

Sparks JL, Burgers PM. Error-free and mutagenic processing of topoisomerase 1-provoked damage at genomic ribonucleotides. EMBO J. 2015 May 5;34(9):1259-69. (PDF)

Williams JS, Clausen AR, Lujan SA, Marjavaara L, Clark AB, Burgers PM, Chabes A, Kunkel TA. Evidence that processing of ribonucleotides in DNA by topoisomerase 1 is leading-strand specific. Nat Struct Mol Biol. 2015 Apr;22(4):291-7. (PDF)

Dovrat D, Stodola JL, Burgers PM, Aharoni A. Sequential switching of binding partners on PCNA during in vitro Okazaki fragment maturation. Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):14118-23. (PDF)

Lin YC, Li L, Makarova AV, Burgers PM, Stone MP, Lloyd RS. Error-prone replication bypass of the primary aflatoxin B1 DNA adduct, AFB1-N7-Gua. J Biol Chem. 2014 Jun 27;289(26):18497-506. (PDF)

Makarova AV, Nick McElhinny SA, Watts BE, Kunkel TA, Burgers PM. Ribonucleotide incorporation by yeast DNA polymerase ζ. DNA Repair (Amst). 2014 Jun;18:63-7. (PDF)

Lin YC, Li L, Makarova AV, Burgers PM, Stone MP, Lloyd RS. Molecular basis of aflatoxin-induced mutagenesis-role of the aflatoxin B1-formamidopyrimidine adduct. Carcinogenesis. 2014 Jul;35(7):1461-8. (PDF)

Northam MR, Moore EA, Mertz TM, Binz SK, Stith CM, Stepchenkova EI, Wendt KL, Burgers PM, Shcherbakova PV. DNA polymerases ζ and Rev1 mediate error-prone bypass of non-B DNA structures. Nucleic Acids Res. 2014 Jan;42(1):290-306. (PDF)

Chon H, Sparks JL, Rychlik M, Nowotny M, Burgers PM, Crouch RJ, Cerritelli SM. RNase H2 roles in genome integrity revealed by unlinking its activities. Nucleic Acids Res. 2013 Mar 1;41(5):3130-43. (PDF)

Kumar S, Burgers PM. Lagging strand maturation factor Dna2 is a component of the replication checkpoint initiation machinery. Genes Dev. 2013 Feb 1;27(3):313-21. (PDF)

Clausen AR, Zhang S, Burgers PM, Lee MY, Kunkel TA. Ribonucleotide incorporation, proofreading and bypass by human DNA polymerase δ. DNA Repair (Amst). 2013 Feb 1;12(2):121-7. (PDF)

Sparks JL, Kumar R, Singh M, Wold MS, Pandita TK, Burgers PM. Human exonuclease 5 is a novel sliding exonuclease required for genome stability. J Biol Chem. 2012 Dec 14;287(51):42773-83. (PDF)

Makarova AV, Stodola JL, Burgers PM. A four-subunit DNA polymerase ζ complex containing Pol δ accessory subunits is essential for PCNA-mediated mutagenesis. Nucleic Acids Res. 2012 Dec;40(22):11618-26. (PDF)

Sparks JL, Chon H, Cerritelli SM, Kunkel TA, Johansson E, Crouch RJ, Burgers PM. RNase H2-initiated ribonucleotide excision repair. Mol Cell. 2012 Sep 28;47(6):980-6. (PDF) (SUP)

Lazzaro F, Novarina D, Amara F, Watt DL, Stone JE, Costanzo V, Burgers PM, Kunkel TA, Plevani P, Muzi-Falconi M. RNase H and postreplication repair protect cells from ribonucleotides incorporated in DNA. Mol Cell. 2012 Jan 13;45(1):99-110. (PDF)

Netz DJ, Stith CM, Stümpfig M, Köpf G, Vogel D, Genau HM, Stodola JL, Lill R, Burgers PM, Pierik AJ. Eukaryotic DNA polymerases require an iron-sulfur cluster for the formation of active complexes. Nat Chem Biol. 2011 Nov 27;8(1):125-32. (PDF)

Navadgi-Patil VM, Kumar S, Burgers PM. The unstructured C-terminal tail of yeast Dpb11 (human TopBP1) protein is dispensable for DNA replication and the S phase checkpoint but required for the G2/M checkpoint. J Biol Chem. 2011 Nov 25;286(47):40999-1007. (PDF)

Watt DL, Johansson E, Burgers PM, Kunkel TA. Replication of ribonucleotide-containing DNA templates by yeast replicative polymerases. DNA Repair (Amst). 2011 Aug 15;10(8):897-902. (PDF)

Stone JE, Kumar D, Binz SK, Inase A, Iwai S, Chabes A, Burgers PM, Kunkel TA. Lesion bypass by S. cerevisiae Pol ζ alone. DNA Repair (Amst). 2011 Aug 15;10(8):826-34. (PDF)

Sparks JL, Chon H, Cerritelli SM, Kunkel TA, Johansson E, Crouch RJ, Burgers PM. RNase H2-initiated ribonucleotide excision repair. Mol Cell. 28;47(6):980-6 (2012). (PDF) (SUP)

Lazzaro F, Novarina D, Amara F, Watt DL, Stone JE, Costanzo V, Burgers PM, Kunkel TA, Plevani P, Muzi-Falconi M. RNase H and post-replication repair protect cells from ribonucleotides incorporated in DNA. Mol Cell. 45(1):99-110 (2012). (PDF)

Netz DJ, Stith CM, Stümpfig M, Köpf G, Vogel D, Genau HM, Stodola JL, Lill R, Burgers PM, Pierik AJ. Eukaryotic DNA polymerases require an iron-sulfur cluster for the formation of active complexes. Nat Chem Biol. 8(1):125-32 (2011). (PDF)

Navadgi-Patil VM, Kumar S, Burgers PM. The unstructured C-terminal tail of yeast Dpb11 (human TopBP1) protein is dispensable for DNA replication and the S phase checkpoint but required for the G2/M checkpoint. J Biol Chem. 286(47):40999-1007 (2011). (PDF)

Burgers PM. It’s all about flaps: Dna2 and checkpoint activation. Cell Cycle. 10(15):2417-8 (2011). (PDF)

Watt DL, Johansson E, Burgers PM, Kunkel TA. Replication of ribonucleotide-containing DNA templates by yeast replicative polymerases. DNA Repair (Amst). 10(8):897-902 (2011). (PDF)

Stone JE, Kumar D, Binz SK, Inase A, Iwai S, Chabes A, Burgers PM, Kunkel TA. Lesion bypass by S. cerevisiae Pol ζ alone. DNA Repair (Amst). 10(8):826-34 (2011). (PDF)

Pike, J.E., Henry, R.A., Burgers, P.M., Campbell, J.L., and Bambara, R.A. An Alternative Pathway for Okazaki Fragment Processing: Resolution of Fold-back Flaps by Pif1 Helicase. J. Biol. Chem. 285, 41712-41723 (2010). (PDF)

Burgers, P.M., Stith, C.M., Yoder, B.L., and Sparks, J.L. Yeast Exonuclease 5 is Essential for Mitochondrial Genome Maintenance . Mol Cell Biol. 30, 4057-4066 (2010). (PDF)

Lydeard, J.R., Lipkin-Moore, Z., Sheu, Y.J., Stillman, B., Burgers, P.M., and Haber, J.E. Break-induced replication requires all essential DNA replication factors except those specific for pre-RC assembly. Genes Dev 24, 1133-1144 (2010). (PDF)

Nick McElhinny, S.A., Watts, B.E., Kumar, D., Watt, D.L., Lundstrom, E.B., Burgers, P.M., Johansson, E., Chabes, A., and Kunkel, T.A. Abundant ribonucleotide incorporation into DNA by yeast replicative polymerases. Proc Natl Acad Sci U S A 107, 4949-4954 (2010). (PDF)

Brown, J.A., Zhang, L., Sherrer, S.M., Taylor, J.S., Burgers, P.M., and Suo, Z. Pre-Steady-State Kinetic Analysis of Truncated and Full-Length Saccharomyces cerevisiae DNA Polymerase Eta. J Nucleic Acids, vol 2010 11 pages (2010). (PDF)

Dallmann, H.G., Tomer, G., Fackelmayer, O.J., Chen, J., Wiktor-Becker, A. Ferrara, T., Oliveira, M.T., Burgers, P.M., Kaguni, L.S., and McHenry, C.S. Parallel Multiplicative Target Screening Against Diverse Bacterial Replicases: Identification of Specific Inhibitors with Broad Spectrum Potential, Biochemistry 49, 2551-2562 (2010). (PDF)

Navadgi-Patil, V., and Burgers, P.M. The unstructured C-terminal tail of the 9-1-1 clamp subunit Ddc1 activates Mec1/ATR via two distinct mechanisms. Mol. Cell, 36, 743-753. (2009).

Li, X., Stith, C.M., Burgers, P.M., and Heyer, W. D. Initiation of recombination-associated DNA synthesis by DNA polymerase delta requires PCNA, Mol. Cell 36, 704-713. (2009).

Stone, J.E., Kissling, G.E., Lujan, S.A., Rogozin, I.B., Stith, C.M., Burgers, P.M., and Kunkel, T.A. Low-fidelity DNA synthesis by the L979F mutator derivative of Saccharomyces cerevisiae DNA polymerase zeta. Nucleic Acids Res 37, 3774-3787 (2009).

McCulloch, S.D., Kokoska, R.J., Garg, P., Burgers, P.M., and Kunkel, T.A. The efficiency and fidelity of 8-oxo-guanine bypass by DNA polymerases delta and eta. Nucleic Acids Res 37, 2830-2840 (2009).

Chon, H., Vassilev, A., DePamphilis, M.L., Zhao, Y., Zhang, J., Burgers, P.M., Crouch, R.J., and Cerritelli, S.M. Contributions of the two accessory subunits, RNASEH2B and RNASEH2C, to the activity and properties of the human RNase H2 complex. Nucleic Acids Res 37, 96-110 (2009).

Sommer, D., Stith, C.M., Burgers, P.M., and Lahue, R.S. Partial reconstitution of DNA large loop repair with purified proteins from Saccharomyces cerevisiae. Nucleic Acids Res 36, 4699-4707 (2008).

Nick McElhinny, S.A., Gordenin, D.A., Stith, C.M., Burgers, P.M., and Kunkel, T.A. Division of labor at the eukaryotic replication fork. Mol Cell 30, 137-144 (2008).

Wardle, J., Burgers, P.M., Cann, I.K., Darley, K., Heslop, P., Johansson, E., Lin, L.J., McGlynn, P., Sanvoisin, J., Stith, C.M., and Connolly, B.A. Uracil recognition by replicative DNA polymerases is limited to the archaea, not occurring with bacteria and eukarya. Nucleic Acids Res 36, 705-711 (2008).

Rossi, M.L., Pike, J.E., Wang, W., Burgers, P.M., Campbell, J.L., and Bambara, R.A. Pif1 helicase directs eukaryotic Okazaki fragments toward the two-nuclease cleavage pathway for primer removal. J Biol Chem 283, 27483-27493 (2008).

Stith, C.M., Sterling, J., Resnick, M.A., Gordenin, D.A., and Burgers, P.M. Flexibility of eukaryotic Okazaki fragment maturation through regulated strand displacement synthesis. J Biol Chem 283, 34129-34140 (2008).

Navadgi-Patil, V.M., and Burgers, P.M. Yeast DNA replication protein Dpb11 activates the Mec1/ATR checkpoint kinase. J Biol Chem 283, 35853-35859 (2008).

McElhinny, S.A., Stith, C.M., Burgers, P.M., and Kunkel, T.A. Inefficient Proofreading and Biased Error Rates during Inaccurate DNA Synthesis by a Mutant Derivative of Saccharomyces cerevisiae DNA Polymerase delta. J Biol Chem 282, 2324-2332 (2007).

McCulloch, S.D., Wood, A., Garg, P., Burgers, P.M., and Kunkel, T.A. Effects of accessory proteins on the bypass of a cis-syn thymine-thymine dimer by Saccharomyces cerevisiae DNA polymerase eta. Biochemistry 46, 8888-8896 (2007).

Chilkova, O., Stenlund, P., Isoz, I., Stith, C.M., Grabowski, P., Lundstrom, E.B., Burgers, P.M., and Johansson, E. The eukaryotic leading and lagging strand DNA polymerases are loaded onto primer-ends via separate mechanisms but have comparable processivity in the presence of PCNA. Nucleic Acids Res 35, 6588-6595 (2007).

Wood, A., Garg, P., and Burgers, P.M. A Ubiquitin-binding Motif in the Translesion DNA Polymerase Rev1 Mediates Its Essential Functional Interaction with Ubiquitinated Proliferating Cell Nuclear Antigen in Response to DNA Damage. J Biol Chem 282, 20256-20263 (2007).

McElhinny, S. A., Stith, C. M., Burgers, P. M., and Kunkel, T. A. Inefficient Proofreading and Biased Error Rates during Inaccurate DNA Synthesis by a Mutant Derivative of Saccharomyces cerevisiae DNA Polymerase delta. J Biol Chem 282, 2324-2332 (2007).

Majka, J., Niedziela-Majka, A., and Burgers, P. M. The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint. Mol Cell 24, 891-901 (2006).

Northam, M. R., Garg, P., Baitin, D. M., Burgers, P. M., and Shcherbakova, P. V. A novel function of DNA polymerase zeta regulated by PCNA. Embo J 25, 4316-4325 (2006).

Majka, J., Binz, S. K., Wold, M. S., and Burgers, P. M. Replication protein A directs loading of the DNA damage checkpoint clamp to 5′-DNA junctions. J Biol Chem 281, 27855-27861 (2006).

Zhong, X., Garg, P., Stith, C. M., McElhinny, S. A., Kissling, G. E., Burgers, P. M., and Kunkel, T. A. The fidelity of DNA synthesis by yeast DNA polymerase zeta alone and with accessory proteins. Nucleic Acids Res 34, 4731-4742 (2006).

Zhuang, Z., Yoder, B. L., Burgers, P. M., and Benkovic, S. J. (2006). The structure of a ring-opened proliferating cell nuclear antigen-replication factor C complex revealed by fluorescence energy transfer. Proc Natl Acad Sci U S A 103, 2546-2551 (2006).

Fortune, J. M., Stith, C. M., Kissling, G. E., Burgers, P. M., and Kunkel, T. A. (2006). RPA and PCNA suppress formation of large deletion errors by yeast DNA polymerase delta. Nucleic Acids Res 34, 4335-4341 (2006).

Garg, P., and Burgers, P. M. Ubiquitinated proliferating cell nuclear antigen activates translesion DNA polymerases eta and REV1. Proc Natl Acad Sci U S A 102, 18361-18366 (2005).

Garg, P., Stith, C. M., Majka, J., and Burgers, P. M. Proliferating Cell Nuclear Antigen Promotes Translesion Synthesis by DNA Polymerase zeta. J Biol Chem 280, 23446-23450 (2005).

Bylund, G. O., and Burgers, P. M. Replication Protein A-Directed Unloading of PCNA by the Ctf18 Cohesion Establishment Complex. Mol Cell Biol 25, 5445-5455 (2005).

Fortune, J. M., Pavlov, Y. I., Welch, C. M., Johansson, E., Burgers, P. M., and Kunkel, T. A. Saccharomyces cerevisiae DNA polymerase delta: high fidelity for base substitutions but lower fidelity for single- and multi-base deletions. J Biol Chem 280, 29980-29987 (2005).

Franco, A. A., Lam, W. M., Burgers, P. M., and Kaufman, P. D. (2005). Histone deposition protein Asf1 maintains DNA replisome integrity and interacts with replication factor C. Genes Dev 19, 1365-1375 (2005).

Majka, J., and Burgers, P. M. Function of Rad17/Mec3/Ddc1 and its partial complexes in the DNA damage checkpoint. DNA Repair (Amst) 4, 1189-1194 (2005).

Jin, Y. H., Garg, P., Stith, C. M., Al Refai, H., Sterling, J., Weston, L., Kunkel, T., Resnick, M. A., Burgers, P. M., and Gordenin, D. A., The multiple biological roles for the 3′-5′-exonuclease of DNA polymerase delta require switching between the polymerase and exonuclease domains, Mol. Cel. Biol., 25, 461-471 (2005).

Corrette-Bennett, S.E., Borgeson, C., Sommer, D., Burgers, P.M.J., and Lahue, R.S. DNA Polymerase delta, RFC, and PCNA are required for repair synthesis of large looped heteroduplexes in Saccharomyces cerevisiae, Nucl. Acids Res., 32, 6268-6274 (2005).

Garg, P., Stith, C.M., Sabouri, N. Johansson, E., and Burgers, P.M., Idling by DNA polymerase delta maintains a ligatable nick during lagging strand DNA replication., Genes Dev., 18, 2764-2773 (2004).

Dzantiev, L., Constantin, N., Genschel, J. Iyer, R. R., Burgers, P. M., and Modrich, P., A defined human system that supports bidirectional mismatch-provoked excision, Molec. Cell, 15, 31-41 (2004).

McCulloch, S.D., Kokoska, R. J., Johansson, E., Welch, C. M., Burgers, P. M., and Kunkel, T.A., Enzymatic switching for efficient and accurate translesion DNA replication, Nucleic Acids Res., 32, 4665-4675 (2004).

Majka, J., Chung, B., and Burgers, P.M., Requirement for ATP by the DNA Damage Checkpoint Clamp Loader, J. Biol. Chem. 279, 20921-20926 (2004).

Dolinsky, T.J., Burgers, P.M., Karplus, K., and Baker, N.A., SprCY: Comparison of structural predictions in the S. cerevisiae genome. Bioinformatics, 20, 3212-3214 (2004).

Johansson, E., Garg, P., and Burgers, P.M., The Pol32 subunit of DNA polymerase delta contains separable domains for processive replication and and proliferating cell nuclear antigen (PCNA) binding. J. Biol. Chem. 279, 1907-1915 (2004).

Majka, J. and Burgers, P.M., Rad17/Mec3/Ddc1, A sliding clamp for the DNA damage checkpoint, Proc Natl Acad Sci USA 100, 2249-2251 (2003).

Jin, Y. H., Ayyagari, R., Resnick, M. A., Gordenin, D. A., and Burgers, P. M., Okazaki Fragment Maturation in Yeast. II. Cooperation between the Polymerase and 3′-5′-Exonuclease Activities of Pol delta in the Creation of a Ligatable Nick. J. Biol. Chem., 278, 1626-1633(2003).

Ayyagari, R., Gomes, X. V., Gordenin, D. A., and Burgers, P. M., Okazaki Fragment Maturation in Yeast. I. Distribution of Functions between FEN1 and Dna2. J. Biol. Chem., 278, 1618-1625 (2003).

Unk, I., Haracska, L., Gomes, X. V., Burgers, P. M., Prakash, L., and Prakash, S., Stimulation of 3′–>5′ exonuclease and 3′-phosphodiesterase activities of yeast apn2 by proliferating cell nuclear antigen. Mol Cell Biol 22, 6480-6486 (2002).

Johansson, E., Majka, J., Burgers, P.M.J., Structure of DNA polymerase delta from S. cerevisiae., J. Biol. Chem. 276, 43824-43828 (2001).

Haracska, L., Unk, I., Johnson, R.E., Johansson, E., Burgers, P.M.J., Prakash, S., Prakash, L., Roles of yeast DNA polymerases delta and zeta and of Rev1 in the bypass of abasic sites. Genes Dev. 15, 945-954 (2001).

Kamath-Loeb A.S., Loeb, L.A., Johansson, E., Burgers, P.M.J., Fry, M. Interactions between the Werner syndrome helicase and DNA polymerase delta specifically facilitate copying of tetraplex and hairpin structures of the d(CGG)n trinucleotide repeat sequence, J. Biol. Chem. 276, 16439-16446 (2001).

Jin, Y. H., Obert, R., Burgers, P. M., Kunkel, T. A., Resnick, M. A., and Gordenin, D.A., The 3′–>5′ exonuclease of DNA polymerase delta can substitute for the 5′ flap endonuclease Rad27/Fen1 in processing Okazaki fragments and preventing genome instability. Proc Natl Acad Sci USA 98, 5122-5127 (2001).

Gomes, X.V., and Burgers, P.M.J., ATP utilization by yeast replication factor C. I. ATP-mediated interaction with DNA and with proliferating cell nuclear antigen, J. Biol. Chem. 276, 34768-34775 (2001).

Gomes, X.V., Gary-Schmidt, S.L., Burgers, P.M.J., ATP utilization by yeast replication factor C. II. Multiple stepwise ATP binding events are required to load proliferating cell nuclear antigen onto primed DNA, J. Biol. Chem. 276, 34776-34783 (2001).

Gary-Schmidt, S.L., Gomes, X.V., Burgers, P.M.J, ATP utilization by yeast replication factor C. III. The ATP-binding domains of Rfc2, Rfc3, and Rfc4 are essential for DNA recognition and clamp loading, J. Biol. Chem. 276, 34784-34791 (2001).

Gary-Schmidt, S.L., Pautz, A.L., Burgers, P.M.J., ATP utilization by yeast replication factor C. IV. RFC ATP-binding mutants show defects in DNA replication, DNA repair, and checkpoint regulation, J. Biol. Chem. 276, 34792-34800 (2001).

MacNeill, S. A., Baldacci, G., Burgers, P. M.J, and Hubscher, U, A unified nomenclature for the subunits of eukaryotic DNA polymerase delta. Trends Biochem Sci 26, 16-17 (2001).

Gomes, X.V., and Burgers, P.M.J., Two modes of FEN1 binding to PCNA regulated by DNA, EMBO J. 19, 3811-3821 (2000).

Kamath-Loeb, A.S., Johansson, E., Burgers, P.M.J., and Loeb, L., Functional interaction between the Werner syndrome protein and DNA polymerase delta, Proc. Natl. Acad. Sci. USA, 97, 4603-4608 (2000).

Gomes, X. V., Gary, S. L., and Burgers, P. M. J., Overproduction in Escherichia coli and characterization of yeast replication factor C lacking the ligase homology domain, J. Biol. Chem., 275, 14541-14549 (2000).

MacNeill, S.A., and Burgers, P.M.J., Chromosomal DNA replication in yeast: genes, enzymes and mechanisms in “The Yeast Nucleus: Frontiers in Molecular Biology” (P. Fantes and J. Beggs, Eds.), Oxford University Press, Oxford, U.K.,pp 19-57 (2000).

Gerik, K.J., Li, X., Pautz, A., and Burgers, P.M.J., Characterization of the two small subunits of Saccharomyces cerevisiae DNA polymerase delta, J. Biol. Chem., 273, 19747-19755 (1998)

Burgers, P.M.J., and Gerik, K.J., Structure and processivity of two forms of Saccharomyces cerevisiae DNA polymerase delta, J. Biol. Chem., 273, 19756-19762 (1998).